What is the recommended action if a patient cannot tolerate an ACE inhibitor?

When a patient cannot tolerate an ACE inhibitor, the recommended action is to administer an angiotensin receptor blocker (ARB). ARBs are commonly used as an alternative in patients who experience side effects from ACE inhibitors, particularly persistent cough or angioedema. Both ACE inhibitors and ARBs work on the renin-angiotensin-aldosterone system (RAAS) to lower blood pressure, but they do so via different mechanisms. By choosing an ARB, you maintain the therapeutic benefits of this pathway while minimizing the likelihood of adverse effects associated with ACE inhibitors.

This approach leverages the overlapping actions of these medications in a manner that continues to provide effective blood pressure control and heart protection. It is essential to follow up with the patient to monitor their tolerance and ensure the desired therapeutic effects are achieved.