What caution should be noted when administering Propofol?

When administering Propofol, a key caution is that it can lead to severe hypotension, especially in volume-depleted patients. Propofol is a potent sedative-hypnotic agent that causes vasodilation, which can significantly lower blood pressure. This effect is particularly pronounced in patients who already have a reduced intravascular volume, such as those who are dehydrated or have undergone significant fluid losses. In these cases, the use of Propofol can exacerbate hypotension and compromise hemodynamic stability, making careful assessment of volume status and monitoring of blood pressure essential during its administration.

The other options address different effects associated with various medications or conditions but do not specifically relate to the primary concerns when using Propofol. For instance, while Propofol can cause bradycardia, this is not its most significant or common adverse effect; similarly, it does not typically lead to increased intracranial pressure, and while it does have sedative effects, prolonged sedation is more closely associated with dosing and duration of administration, rather than a primary caution. Hence, monitoring for hypotension in volume-depleted patients is critical when considering the use of Propofol.