In case of prolonged seizures, which route is preferred for lorazepam administration?

The preferred route for lorazepam administration in the case of prolonged seizures is intravenous. This method allows for rapid onset of action, which is crucial in managing status epilepticus—a condition characterized by prolonged or repeated seizures. Administering lorazepam intravenously results in higher plasma concentrations more quickly, facilitating immediate therapeutic effects.

The intravenous route is also advantageous in acute settings where patients may not be able to take medications orally due to altered levels of consciousness or swallowing difficulties. This ensures that treatment can be initiated without delay, which is essential in preventing potential complications associated with prolonged seizures, such as brain injury.

Other routes, such as intramuscular or subcutaneous, may provide slower absorption and delayed effects, making them less suitable in urgent situations. Oral administration is also impractical in acute seizure scenarios due to the need for rapid intervention and potential inability of the patient to safely ingest medication.