At what infusion rate does dobutamine start to exert its effects?

Dobutamine is a medication primarily used for its positive inotropic effects on the heart, which means it increases the strength of heart muscle contractions, as well as improving cardiac output. The infusion rate at which dobutamine begins to exert its effects typically ranges from 5 to 20 micrograms per kilogram per minute. At this dose range, dobutamine effectively stimulates beta-adrenergic receptors, which enhances myocardial contractility and can lead to improved hemodynamics in patients experiencing heart failure or septic shock.

Lower doses, such as those given in the other ranges, often do not provide sufficient stimulation of these receptors to achieve the intended therapeutic effects associated with dobutamine use. Thus, the specified range of 5-20 micrograms per kilogram per minute is recognized clinically as the threshold for dobutamine's beneficial actions in enhancing cardiac function and is supported by pharmacological evidence in critical care settings.